Mesenchymal stem cell therapy

    Mesenchymal stem cells or mesenchymal stromal cells (MSCs) are adult stem cells found in a wide range of human tissues, including bone marrow, fat tissue, muscle tissue, umbilical blood, umbilical cord, and placental, etc.  

MSCs possess three main features:

     1) they can differentiate into fat cells, cartilage cells, and bone cells;

     2) they can secret a variety of trophic factors that help cell regeneration and tissue repair; 

    3) they have immuno-modulator function that helps keeping immune system in balance;

Since MSCs are immune privileged and will not be attacked by body’s immune system, allogeneic cell infusion is safe. Over the past two decades, MSCs have been viewed as a highly promising strategy in regenerative medicine. 

    There are thousands of clinical trials have been carried out using MSCs and most of them demonstrated excellent safety and good efficacy for targeted diseases.  As one of our core business, CIB has developed a proprietary technology to make clinical grade mesenchymal stem cells from umbilical cord. In particular, we have developed a proprietary protocol that uses small molecules to precondition MSCs, which significantly boosts immunosuppression efficacy of conditioned MSCs compared to non-conditioned MSCs. Our current therapeutic focusing area is treatment of common autoimmune diseases such as Systemic Lupus Erythematosus, Rheumatoid Arthritis, Psoriasis, and Inflammatory Bowl Diseases (Crohn’s Disease and Ulcerative Colitis). Over the past a few years, we have established robust culture conditions and cGMP manufacturing process that controls batch-to-match variation of MSC production. Currently, we are collaborating with several “triple A” hospitals in Hainan, LeYang, and Shandong to conduct clinical trials on various autoimmune diseases.

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